Bedspreads and Comforter Sets - What's the Difference Most people use the phrases bedspreads and comforter sets interchangeably, and they don't make a distinction between a bedspreads and comforter sets as a result escalating the acceptance of comforters over the years. Size Matters Bedspreads and comforter sets are usually not the same and also have unique origins. The main difference between the bedspread ...